Associate Scientist, Translational Pharmacology
Company: AnaptysBio Inc
Location: San Diego
Posted on: September 18, 2024
|
|
Job Description:
AnaptysBio IncAll qualified applicants will receive
consideration for employment without regard to race, color, sex,
sexual orientation, gender identity, religion, national origin,
disability, veteran status, age, marital status, pregnancy, genetic
information, or other legally protected status.Description:Works
independently to design, perform, interpret, and record in vitro
cellular functional assays with lead candidate antibodies to
achieve program goals within the translational pharmacology group
and project team. Responsibilities include developing and executing
cell-based functional assays with cell lines, primary cells, whole
blood, PBMCs and sub-populations of immune cells from both normal
and disease donors to understand the biology of targets, evaluate
the pharmacology of lead antibody candidates, support translational
studies, and analyze in vivo pharmacology (PK/PD) relationships.
Additional responsibilities include evaluating activity of
antibodies from AnaptysBio's discovery platforms to support
antibody drug screening, target validation, mechanism-of-action
studies, biomarker identification, and/or companion diagnostics
development. Requires deep knowledge and application of both
theoretical and technical aspects of experimental methods from
relevant scientific literature. Requires the ability to think
critically, understand data analysis and presentation, and
communicate experimental findings in both individual and team
settings. Essential FunctionsIsolate and purify primary cells from
multiple sources (blood, spleen, skin) and species (human, NHP,
mouse)Perform mammalian tissue culture, including both established
cell lines and primary immune cellsDevelop and optimize in vitro
functional assays for T, B cells, myeloid cells, including both
basic and more complex co-culture systems, such as cell
proliferation, cell signaling, and cytokine productionPerform high
dimensional flow cytometry (both surface and intracellular markers)
and cytokine analysis using ELISA, MSD, and/or Luminex
platformsAnalyze complex scientific datasets using GraphPad PRISM
to interpret translational pharmacologyCollaborate effectively with
team members in other departments (Molecular Biology, Protein
Sciences, Mechanism of Action, In vivo) to achieve program goals
Present experimental results and make recommendations for
action/further research at project and department meetingsPrepare
research reports for transfer to external CRO/collaborators, patent
applications, and posters/manuscriptsFormulate experimental plans
to achieve scientific goals in new and creative
waysRequirements:Bachelor's degree in a relevant scientific
discipline (biology, immunology, translational pharmacology, or
related field) with 10 years related laboratory experience or
equivalentKnowledge and Competencies: Deep knowledge and working
experience in principles and techniques of cellular immunology,
cell biology, and translational pharmacology (cell culture, in
vitro cell-based functional assays, flow cytometry, analyte
platforms, familiarity with animal models of autoimmune disease and
PK/PD principles)Experience in industry drug discovery workflow,
from linking antibody screening to in vitro/ in vivo translational
assays that support program advancement and IND filing Antibody
discovery experience in screening assaysScientific independence,
ability to work with limited supervision, ability to collaborate
effectively within team setting and cross-functionally with other
departmentsAbility to quickly implement standard approaches and
ensure experiments are well-designed and performed to a high
standardAbility to develop, apply, and troubleshoot new methods to
address specific scientific questions Proficiency in data analysis
and presentation applications (Flowjo, Diva, Novoexpress, etc.;
ELN/Benchling, Word, Excel, Powerpoint) Desired ExperienceEx vivo
human or animal explant systems to evaluate tissue pharmacology
(for example involving TEER, cell migration, organoids,
fibrosis).Quantitative pharmacology of target and therapeutic
antibody trafficking using live-cell imaging, high-content imaging,
and immune synapse formation assaysDevelopment of PK/ADA assays for
therapeutic antibodies Molecular immunology to support
translational medicine approaches (scRNAseq, spatial
transcriptomics, multiplex IHC) Development of new methods for
antibody discovery leveraging novel molecular and/or cell
biologyManagement/mentorship of more junior scientistsPhysical
DemandsThe physical demands described here are representative of
those that must be met by an employee to successfully perform the
essential functions of this job. Reasonable accommodations may be
made to enable individuals with disabilities to perform the
essential functions.While performing the duties of this job, the
employee is regularly required to sit and talk or hear. The
employee frequently is required to use hands to finger, handle, or
feel. The employee is occasionally required to stand, walk, and
reach with hands and arms. The employee must occasionally lift
and/or move up to 10 pounds. Specific vision abilities required by
this job include close vision and ability to adjust focus in order
to read.Work EnvironmentThe work environment characteristics are
representative of those an employee encounters while performing the
essential functions of this job, typically in an open office
environment. Reasonable accommodations may be made to enable
individuals with disabilities to perform the essential
functions.The noise level in the work environment is usually
moderate.May be required to travel by plane or car.This position
requires working with biological and/or chemical hazards.All
qualified applicants will receive consideration for employment
without regard to race, color, sex, sexual orientation, gender
identity, religion, national origin, disability, veteran status,
age, marital status, pregnancy, genetic information, or other
legally protected status Compensation details: 101000-131000 Yearly
SalaryPI5b0af5f8387b-25660-34886081
Keywords: AnaptysBio Inc, Indio , Associate Scientist, Translational Pharmacology, Other , San Diego, California
Click
here to apply!
|